Abh cream for agitation dose

1. Evidence suggests that haloperidol was useful in reducing aggression, but was associated with adverse effects; there was no evidence to support the routine use of this drug for other manifestations of agitation in dementia. 2. Similar drop-out rates among haloperidol and placebo treated patients suggested that poorly controlled symptoms, or ...

For oral dosage form (oral solution): For anxiety: Adults and children 12 years of age and older—2 to 6 milligrams (mg) in divided doses per day. Your doctor may adjust your dose as needed. Older adults—At first, 1 to 2 mg in divided doses per day. Your doctor may adjust your dose as needed.This study investigated the efficacy of "ABH," a topical gel containing lorazepam (Ativan), diphenhydramine (Benadryl), and haloperidol (Haldol), in reducing breakthrough CINV.Aug 20, 2022 · If you take Ativan for anxiety, you’ll be prescribed the tablet form of the drug. Ativan’s dosage for anxiety ranges from 1 mg per day up to 10 mg per day. But the usual dosage is 2 mg or 3 mg ... Although ABH gel is also used in the setting of terminal agitation at the end of life, published evidence does not exist for efficacy in this setting. However, there is much anecdotal evidence from patients and caregivers through forums and message boards …You can also use phenergan ,haldol and ABH (ativan ,benadryl and haldol) in the form of a topical gel. I use this more with combative residents than hospice (but I still use it somewhat frequently) because we use intensol (which is so much better)Uses. This medication is used to treat anxiety. Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves ( central nervous system) to produce a calming ...May 20, 2006 ... The common dosage is 0.25 mL applied to the inner wrist four times a day. Table 2 summarizes the drug classes, nausea and vomiting pathways ...For insomnia due to anxiety or transient situational stress, a single daily dose of 1-2 mg may be given, usually at bedtime. For elderly or debilitated patients, an initial dosage of 1 or 2 mg/day in dividd e doses is recommended, to be adjusted as needed and tolerated. The need for continued therapy with ATIVAN in patients who have been

Mô tả. Aphaxan được sử dụng trong các trường hợp sau như giảm đau, kháng viêm trong các trường hợp cơ khớp đau do chấn thương, thấp khớp, viêm thần kinh như đau lưng, vẹo cổ, bong gân, căng cơ quá mức, gãy xương, trật khớp, đau sau phẫu thuật. Điều trị cảm sốt, nhức ...Objectives: The primary objective is to characterize the dose of prn oral IR quetiapine used to manage acute agitation or aggression in a pediatric ED. Secondary objectives include characterizing the dose of prn oral IR haloperidol, loxapine, and chlorpromazine; and describing the 1-hour response rate, admission rate, length of stay (LOS), and ...For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended, to be adjusted as needed and tolerated. The dosage of Ativan (lorazepam) should be increased gradually when needed to help avoid adverse effects. When higher dosage is indicated, the evening dose should be increased before the daytime doses.For treating anxiety, the maximum dosage of Ativan in 24 hours is 10 mg. For treating status epilepticus, the maximum dose of Ativan per seizure episode is 8 mg. When used before surgery, the ...For oral dosage form (oral solution): For anxiety: Adults and children 12 years of age and older—2 to 6 milligrams (mg) in divided doses per day. Your doctor may adjust your dose as needed. Older adults—At first, 1 to 2 mg in divided doses per day. Your doctor may adjust your dose as needed. Children younger than 12 years of age—Use and ...

Dependence and Withdrawal Reactions. cont. benzodiazepine use may lead to clinically significant physical dependence; risk of dependence and withdrawal incr. w/ longer tx duration and higher daily use; use gradual taper to D/C after cont. use as abrupt D/C or rapid dose reduction may cause acute withdrawal reactions, potentially life-threatening.Fluoxetine (Reconcile or Prozac) Lorazepam (Ativan) Paroxetine (Paxil) Sertraline (Zoloft) 1. Alprazolam (Xanax) Indications: phobias, fear, panic disorders. Alprazolam is often prescribed to help dogs who become anxious during thunderstorms, but it may also be used for other types of situational anxiety.Ativan Dosage: Ativan is a medication for Treatment of Anxiety. Dosage of Ativan depends upon severity of Anxiety. For severe Anxiety, dose can be 1mg three times a ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. Promethazine 25mg transdermal gel, ABHR (Ativan 1mg/Benadryl 12.5mg/Haldol 0.5mg/Reglan 10mg) or ABH (Ativan/Benadryl/Haldol) gel are very effective …The topical gel known as "ABH gel," comprising lorazepam (Ativan (®)), diphenhydramine (Benadryl (®)), and haloperidol (Haldol (®)), is frequently used to treat nausea because of its perceived efficacy, relatively low cost, and ease of use in the home setting.Ativan tablets are available in the following doses: 0.5 mg. 1 mg. 2 mg. Ativan also comes as an oral liquid; the typical dosage for the liquid form is 2 mg per mL. The daily dose for Ativan can range anywhere from 1 mg to 10 mg. However, for anxiety disorders, a common dose of Ativan is 2 mg to 6 mg, two to three times per day as needed ...

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The pathophysiology of nausea and vomiting, whether induced by chemotherapy or other causes, is complex. It involves multiple organ systems, including primarily the central nervous system, the ...et al (7) looked at the absorption of ABH gel through the skin of normal volunteers. This study used a 1ml dose of lorazepam 2mg/ml, Benadryl 25mg/ml and Haldol 2mg/ml applied to the skin. Blood samples were drawn at 0, 30, 60, 90, 120, and 240 minutes. Plasma concentrations were analyzed by liquid chromatography. TheAdult: 2 to 5 mg once daily at bedtime for 7 days max. Agitation. Adult: 10 mg single dose ... The cream and ointment are interchangeable. However, preferably use ...The topical gel known as "ABH gel," comprising lorazepam (Ativan (®)), diphenhydramine (Benadryl (®)), and haloperidol (Haldol (®)), is frequently used to treat nausea because of its perceived efficacy, relatively low cost, and ease of use in the home setting.Nov 24, 2020 ... Despite a lack of evidence of benefit, the compounded product ABH gel (lorazepam, diphenhydramine, and haloperidol) continues to be ...10 healthy volunteers, age 25-58 (mean 37), 2 African-American and 8 Caucasian-American, applied the standard 1.0 ml dose (2 mg of lorazepam, 25 mg of diphenhydramine, and 2 mg of haloperidol in a pluronic lecithin organogel) rubbed on …

2 min read People with Alzheimer's disease can get anxious or upset easily. They might be restless, unable to sleep, or pace back and forth. These problems, called agitation, can keep them from a...10.1002/14651858.CD002852. Agitation occurs in up to 70% of demented patients. Haloperidol has been used for decades to control agitation in dementia, but its effectiveness remains unclear. Previous meta-analyses examined only English language publications or compared haloperidol with other drugs rather than with placebo. Jun 1, 2023 · Store Ativan tablets tightly closed at room temperature, away from moisture and heat. Keep your medicine in a place where no one can use it improperly. Dosing information. Usual Adult Dose for Anxiety: Initial dose: 2 to 3 mg orally per day, given 2 to 3 times per day Maintenance dose: 1 to 2 mg orally 2 to 3 times a day Uses: The maximum dose of Ativan in 24 hours is 10 milligrams (mg). This dose is typically taken for conditions that are treated with Ativan tablets, such as anxiety.. The 10-mg maximum dose is usually ...May 6, 2023 · For oral dosage form (oral solution): For anxiety: Adults and children 12 years of age and older—2 to 6 milligrams (mg) in divided doses per day. Your doctor may adjust your dose as needed. Older adults—At first, 1 to 2 mg in divided doses per day. Your doctor may adjust your dose as needed. For this update, we identified one RCT which compared ABH gel, containing haloperidol, diphenhydramine and lorazepam, with placebo (Fletcher 2014). However haloperidol is not absorbed significantly from topical application of ABH gel (Smith 2012a) so this study does not add to the evidence base for the effectiveness of haloperidol as an …The usual oral dosage for Ativan tablets is 2 to 6 mg daily. This dosage amount is usually divided and taken two or three times daily. Dosage of Ativan tablets for anxiety. Typical dosage: 2 to 3 ...Sep 13, 2021 · Rapid Agitation Control With Ketamine in the Emergency Department: A Blinded, Randomized Controlled Trial. Ann Emerg Med. 2021 Aug 2:S0196-0644 (21)00433-9. doi: 10.1016/j.annemergmed.2021.05.023 PMID: 34353650. This is another single-center, randomized trial looking at IM ketamine in agitated patients.

Reduce dose in renal impairment. Common dose range is 300 – 600 mg po tid. Consider reducing opioid dose as gabapentin dose is titrated up. Bioavailability is lower with higher doses. Pregabalin Usual frequency is bid (or tid). Start at 25 mg po bid; titrate up over 2 days. Common dose is 50 – 100 mg po bid, up to 150 mg bid.

Mar 22, 2012 · Antinausea Gel Not Absorbed at Therapeutic Levels. DENVER – Compounded ABH gel is widely prescribed for treatment of nausea in the hospice setting. It costs less than $1 per dose. Side effects are rare. And many clinicians swear by its effectiveness, noting that the constituent medications in ABH gel – Ativan (lorazepam), Benadryl ... Dosage: Start at the lowest possible dose (0.5–1 mg) orally and titrate in increments if necessary, after an interval of 2 hours until there is a clinical response [Inouye, 2014; British Geriatrics Society, 2019].The maximum dose in 24 hours should not exceed 2 mg [Healthcare Improvement Scotland, 2014].Review the person regularly and discontinue …For the primary purpose of sedation and relief of anxiety, the usual recommended initial dose of lorazepam for intravenous injection is 2 mg total, or 0.02 mg/lb (0.044 mg/kg), whichever is smaller. This dose will suffice for sedating most adult patients and ordinarily should not be exceeded in patients over 50 years of age.well as anti-depressants, anti-anxiety drugs, and hypnotics. 1 The quality of care, and pharmacy regulations are located at sections 483.25 and 483.45, respectively, of Title 42 of the Code of Federal Regulations. A Closer Look at the Revised Nursing Facility Regulations Unnecessary Drugs and Antipsychotic Medications Acknowledgements haloperidol 5 mg IM (use lowest effective dose of haloperidol due to increased risk of EPS in delirious patients) or IV (with caution) Avoid BZD o Agitation due to EtOH or BZD withdrawal or CNS stimulant intoxication (e.g., amphetamines, synthetic cannabinoids) Oral BZD: lorazepam 1-2 mg, diazepam 5-10 mgLorazepam is a medicine used for short-term treatment of anxiety disorders. The intravenous form of lorazepam is used to treat seizures. Lorazepam is in a class of drugs called benzodiazepines. It ...emerging as a promising noninvasive method of minimal sedation in children before anxiety-producing events by rapidly delivering the medication (Fantacci et al, 2018). The dosage of intranasal midazolam (INM) is typically 0.2-0.3 mg/kg. The dose can be repeated within 5 to 15 minutes to a maximum dose of 0.5mg/kg.Lorazepam (Ativan), diphenhydramine (Benadryl), haloperidol (Haldol) ("ABH") topical gel is currently widely used for nausea in hospice due to perceived efficacy and low cost, and has been suggested for cancer chemotherapy. However, there are no studies of absorption, a prerequisite for effectiveness.

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For oral dosage form (oral solution): For anxiety: Adults and children 12 years of age and older—2 to 6 milligrams (mg) in divided doses per day. Your doctor may adjust your dose as needed. Older adults—At first, 1 to 2 mg in divided doses per day. Your doctor may adjust your dose as needed.Lorazepam is a benzodiazepine that is widely used for management of acute agitation. Despite its widespread use, there is remarkably little clinical evidence for the benefits of lorazepam in acute agitation. We performed a systematic review with focus on lorazepam, including all randomized clinical trials on lorazepam in mental and behavioral ...10.1002/14651858.CD002852. Agitation occurs in up to 70% of demented patients. Haloperidol has been used for decades to control agitation in dementia, but its effectiveness remains unclear. Previous meta-analyses examined only English language publications or compared haloperidol with other drugs rather than with placebo.emerging as a promising noninvasive method of minimal sedation in children before anxiety-producing events by rapidly delivering the medication (Fantacci et al, 2018). The dosage of intranasal midazolam (INM) is typically 0.2-0.3 mg/kg. The dose can be repeated within 5 to 15 minutes to a maximum dose of 0.5mg/kg.Ativan tablets are available in the following doses: 0.5 mg. 1 mg. 2 mg. Ativan also comes as an oral liquid; the typical dosage for the liquid form is 2 mg per mL. The daily dose for Ativan can range anywhere from 1 mg to 10 mg. However, for anxiety disorders, a common dose of Ativan is 2 mg to 6 mg, two to three times per day as needed ...Truly, the continued use of ABH gel makes for a pricey placebo and delays the treatment of end-of-life symptoms with modalities that work. Keywords: Benzodiazepines; …Lidocaine H 1%/Diphenhydramine HCI 2%/Dexamethasone 0.5%/Cimetidine 4% Topical Cream Lidocaine HCI 1%/Diphenhydramine HCI 2%/Dexamethasone 0.5%/Cimetidine 4% Topical Gel Anal Fissures Nifedipine 0.2% Ointment Nitroglycerin 0.2%/Misoprostol 0.002%/Phenytoin 0.2% ointment Anxiety Midazolam 12.5 mg Sorbitol Lollipop BaseA 2006 double-blind RCT examined 421 outpatients (median age = 77.9 years ± 7.5 years; 56% female) with Alzheimer dementia and psychosis, aggression, or agitation who were randomly assigned to ...The topical gel known as "ABH gel," comprising lorazepam (Ativan (®)), diphenhydramine (Benadryl (®)), and haloperidol (Haldol (®)), is frequently used to treat nausea because of its perceived efficacy, relatively low cost, and ease of use in the home setting.The topical gel known as "ABH gel," comprising lorazepam (Ativan (®)), diphenhydramine (Benadryl (®)), and haloperidol (Haldol (®)), is frequently used to treat nausea because of its perceived efficacy, relatively low cost, and ease of use in the home setting.During the six-week trial, 71 outpatients with Alzheimer's disease were randomized to receive a “standard” dosage of haloperidol (2 to 3 mg per day), a “low” dosage of haloperidol (0.50 to ...Ketamine as Rescue Treatment for Difficult-to-Sedate Severe Acute Behavioral Disturbance in the Emergency Department. Ann Emerg Med. 2016 May;67 (5):581-587. PMID: 26899459. Riddell J, Tran A, Bengiamin R, Hendey GW, Armenian P. Ketamine as a first-line treatment for severely agitated emergency department patients. ….

Common dose ranges are as follows: 0.5 to 2.0 mg/mL for lorazepam, 12.5 to 25.0 mg/mL for diphenhy- dramine, and 0.5 to 2.0 mg/mL of haloperidol. 2e6 Application of ABH gel is typically to the volar or palmar surface of the wrists, rubbed behind the ears or the bottoms of the feet.For this update, we identified one RCT which compared ABH gel, containing haloperidol, diphenhydramine and lorazepam, with placebo (Fletcher 2014). However haloperidol is not absorbed significantly from topical application of ABH gel (Smith 2012a) so this study does not add to the evidence base for the effectiveness of haloperidol as an …Compare Ativan vs Valium head-to-head with other drugs for uses, ratings, cost, side effects and interactions. ... Ativan may be used for the treatment of anxiety or as a preoperative medicine. It is potentially addictive and a withdrawal syndrome may be experienced upon discontinuation. ... Dosage: 1 mg: Per Unit * $46.83: Cost * View all ...As commonly used, none of the lorazepam, haloperidol, or diphenhydramine in ABH gel is absorbed in sufficient quantities to be effective in the treatment of nausea …Cat Dosage. Tranquilizer. Acepromazine. 0.5–2 mg/kg, prn a to tid. 0.5–2 mg/kg, prn. Benzodiazepines. Alprazolam. 0.01–0.1 mg/kg, prn to qid. 0.125–0.25 mg/cat, prn to tid. Clonazepam. 0.1–1 mg/kg, bid-tid. 0.05–0.2 mg/kg, one to three times/day. Clorazepate. 0.5–2 mg/kg, prn to tid.Such symptoms can greatly diminish the hospice patient's quality of life. Effective pharmacotherapy is available, but in many cases traditional dosage forms are ...Jun 1, 2007 ... Nausea, vomiting, agitation, and anxiety are common symptoms found in hospice patients approaching end-of- life. The use of Transdermal ABHR ...The usual oral dosage for Ativan tablets is 2 to 6 mg daily. This dosage amount is usually divided and taken two or three times daily. Dosage of Ativan tablets for anxiety. Typical dosage: 2 to 3 ... Abh cream for agitation dose, Truly, the continued use of ABH gel makes for a pricey placebo and delays the treatment of end-of-life symptoms with modalities that work. Keywords: Benzodiazepines; antipsychotic agents; hospice care; nausea; palliative supportive care; psychomotor agitation; vomiting., An IM dose of 10 mg can be administered every 4 hours if needed for alcohol withdrawal. Lorazepam (Ativan®): The initial dose is 0.5 mg twice a day; the dose can be increased by 1 mg daily in divided doses (twice daily or three times a day); the usual therapeutic dose is 2-8 mg total/day, with twice daily or three times a day dosing., Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms; Usual Pediatric Dose for Anxiety. ORAL: 12 years or older: Initial dose: 2 to 3 mg orally per day, given 2 to 3 times per day; Maintenance dose: 1 to 2 mg orally 2 to 3 times a day; The daily dosage may vary from 1 to 10 mg/day., Cyclic vomiting syndrome (CVS) is an idiopathic disorder characterized by recurrent, stereotypical bouts of vomiting with intervening periods of normal or baseline health [ 1 ]. Both children and adults are affected, although the clinical presentation and natural history vary somewhat with age [ 2-6 ]., For this update, we identified one RCT which compared ABH gel, containing haloperidol, diphenhydramine and lorazepam, with placebo (Fletcher 2014). However haloperidol is not absorbed significantly from topical application of ABH gel (Smith 2012a) so this study does not add to the evidence base for the effectiveness of haloperidol as an …, Ativan tablets are available in the following doses: 0.5 mg. 1 mg. 2 mg. Ativan also comes as an oral liquid; the typical dosage for the liquid form is 2 mg per mL. The daily dose for Ativan can range anywhere from 1 mg to 10 mg. However, for anxiety disorders, a common dose of Ativan is 2 mg to 6 mg, two to three times per day as needed ..., A 1 mL volume of ABH gel was applied to the volar wrists for total amounts of 2 mg lorazepam, 25 mg diphenhydramine, and 2 mg haloperidol. Drug concentrations were checked at Time 0, 30, 60, 90, 120, 180, and 240 minutes. The 240 minute (six hour) time limit was used because the ABH gel is being recommended as an every four to six hour ..., Uses. This medication is used to treat anxiety. Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves ( central nervous system) to produce a calming ... , Promethazine 25mg transdermal gel, ABHR (Ativan 1mg/Benadryl 12.5mg/Haldol 0.5mg/Reglan 10mg) or ABH (Ativan/Benadryl/Haldol) gel are very effective nausea/vomiting treatments. ABHR can be compounded as rectal suppositories as well. In addition, Dexamethasone can also be added to the preparations to provide more relief.", 30mg or 60mg per serving. Formulated to support stress-relief, promote quality sleep, and reduce pain. Rigorously test every batch of product to ensure our standards of quality and safety are met ..., The common dosage is 0.25 mL applied to the inner wrist four times a day. Table 2 summarizes the drug classes, nausea and vomiting pathways affected, therapeutic effects, and side effects of the ..., Nov 14, 2019 · The typical dosage is 5-10 mg IM, though it was once standard practice to administer as needed (up to 60 mg per day) until sedation was achieved. Seeing as the effects are unlikely to be dose-dependent, this practice is no longer supported. Among typical antipsychotics, haloperidol is the drug of choice in the rapid tranquilization setting. , Lorazepam (lore-AY-zuh-pam) reduces anxiety, agitation, shortness of breath, and insomnia. Commonly available under the brand name Ativan or Lorazepam Intensol, it comes in either a tablet or liquid and is taken by mouth.. Lorazepam is the second most-prescribed hospice medication. It can be given alongside morphine (described below) if …, Check for physical reasons they might be agitated, like hunger, thirst, needing to use the bathroom, or being too hot or cold. Exercise can ease anxiety and stress. Take them for a walk, do some ..., Lorazepam, diphenhydramine, haloperidol, and metoclopramide are the drugs contained in the compounded gel commonly referred to as ABHR. The gel was …, Adult. 2–10 mg daily in 1–2 divided doses; usual dose 2–4 mg daily, in first-episode schizophrenia, up to 10 mg daily, in multiple-episode schizophrenia, dose adjusted according to response at intervals of 1–7 days. Individual benefit-risk should be assessed when considering doses above 10 mg daily; maximum 20 mg per day. Elderly., Effective pharmacotherapy is available, but in many cases traditional dosage forms are incompatible with the patient's physical condition, cause discomfort, or are difficult for …, A 2006 double-blind RCT examined 421 outpatients (median age = 77.9 years ± 7.5 years; 56% female) with Alzheimer dementia and psychosis, aggression, or agitation who were randomly assigned to ..., Jun 1, 2007 ... Nausea, vomiting, agitation, and anxiety are common symptoms found in hospice patients approaching end-of- life. The use of Transdermal ABHR ..., Effective pharmacotherapy is available, but in many cases traditional dosage forms are incompatible with the patient's physical condition, cause discomfort, or are difficult for …, Haloperidol is used to treat nervous, emotional, and mental conditions (eg, schizophrenia). It is also used to control the symptoms of Tourette's disorder. This medicine should not be used to treat behavior problems in older adult patients who have dementia. Haloperidol is also used to treat severe behavioral problems (eg, aggressive, impulsive ... , This study investigated the efficacy of "ABH," a topical gel containing lorazepam (Ativan), diphenhydramine (Benadryl), and haloperidol (Haldol), in reducing breakthrough CINV. Adults receiving standard recommended prophylactic antiemetics as outpatients were instructed to use 0.5 mL of the gel topically when they experienced significant CINV., 30mg or 60mg per serving. Formulated to support stress-relief, promote quality sleep, and reduce pain. Rigorously test every batch of product to ensure our standards of quality and safety are met ..., Parenteral medication, administered intramuscularly in doses of 2 to 5 mg, is utilized for prompt control of the acutely agitated schizophrenic patient with moderately severe to very severe symptoms. Depending on the response of the patient, subsequent doses may be given, administered as often as every hour, although 4 to 8 hour intervals may ..., ABH PLO Topical Gel. Ingredients and/or Strength Lorazepam 1 mg/mL Diphenhydramine 12.5 mg/mL Haloperidol 2 mg/mL. How to Prescribe Apply 1 ml to inner wrist for nausea …, Jan 1, 2021 · Although ABH gel is also used in the setting of terminal agitation at the end of life, published evidence does not exist for efficacy in this setting. However, there is much anecdotal evidence from patients and caregivers through forums and message boards on the Internet. Digging Deeper: Why ABH Gel May Have Positive Effects , Ativan is a medication that’s used in the treatment of anxiety disorders. Though an overdose can occur if more than the recommended dose is ingested, death is not a likely result of overdosing on Ativan. There is no conclusive research on the lethal dose of Ativan. A normal dose of Ativan is between 2 to 6 milligrams (mg)., May 9, 2016 · Chemical sedation is part of the array of options to treat acute agitation. Prevention strategies, verbal de-escalation techniques, and physical restraints also play a role in the prevention and management of acute agitation. The ideal first line medications to use for rapid tranquilization of an acutely agitated patient are benzodiazepines and ... , 10 healthy volunteers, age 25-58 (mean 37), 2 African-American and 8 Caucasian-American, applied the standard 1.0 ml dose (2 mg of lorazepam, 25 mg of diphenhydramine, and 2 mg of haloperidol in a pluronic lecithin organogel) rubbed on the volar surface of the wrists by the subject. , Background: Acute agitation in the pediatric emergency department (ED) has the potential to escalate into aggression and result in harm. Rapid and effective management may be warranted. Use of pro re nata (prn) oral immediate-release (IR) quetiapine, haloperidol, loxapine, and chlorpromazine has been observed in the pediatric ED at Surrey Memorial …, The topical gel known as "ABH gel," comprising lorazepam (Ativan (®)), diphenhydramine (Benadryl (®)), and haloperidol (Haldol (®)), is frequently used to treat nausea because of its perceived efficacy, relatively low cost, and ease of use in the home setting., Acute agitation in the emergency department is a common issue that frequently requires the use of chemical sedation to preserve safety for patients and healthcare workers. A commonly employed treatment regimen is the combination of haloperidol 5 mg + lorazepam 2 mg + diphenhydramine 50 mg (B-52). Diphenhydramine is included in this treatment ..., Treatment of psychomotor agitation. Drug selection — Benzodiazepines are used to treat the psychomotor agitation most patients experience during withdrawal and to prevent progression from minor withdrawal symptoms to major ones [29-31,34,38-42]. The appropriate use of phenobarbital as an adjunct therapy is discussed below.