Higuchi connors phase solubility techniques

Abstract. Levemopamil was solubilized by varying the concentration of hydroxypropyl- β -cyclodextrin (HP β CD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HP β CD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HP β CD concentration of the charged ...

[Article] - Phase Solubility Techniques I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv.Mar 10, 2023 · Phase-solubility profiles and classification of drug/CD complexes according to Higuchi and Connors . Figure 2. In general, one drug molecule (D) forms a complex with one CD molecule in pure water, and, if the complex is water-soluble, an A L -type phase-solubility diagram is observed ( Table 1 ). Phase solubility studies. Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α ...Phase Solubility Studies. These studies were performed to select the stoichiometry of FLF - β-CD and FLF - β-CD - Soluplus® using the described method by Higuchi-Connors . Briefly, different concentrations of β-CD solutions (2–12 mM) were prepared, and an excess quantity of FLF was added to the solution.Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; ChemistrySolubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on …The mole fraction solubility of TDL was found to be highest in pure PEG 400 (1.86 × 10- 2 at 298.15 K) as compared to water (5.7 × 10- 7 at 298.15 K). The thermophysical parameters such as enthalpies and entropies for TDL dissolution indicated that the dissolution of TDL is endothermic and an entropy-driven process.PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE J Pharm Sci. 1964 Nov;53:1325-8. doi: 10.1002/jps.2600531108. Authors L W DITTERT, T HIGUCHI, D R REESE. PMID: 14253586 DOI: 10.1002/jps.2600531108 No abstract available. MeSH terms Chemistry, Pharmaceutical* ...

Solubility studies used deionized water, and 1 H NMR spectra were of solutions in deuterium oxide (D 2 O, deuterium content 99.8%) from Fluka (Barcelona, Spain). 2.2. Phase solubility studiesSolubility measurements were carried out according to the method of Higuchi and Connors (1965). Excess amounts of clofibrate were added to a series of ...The phase solubility technique permits the evaluation of the affinity between HPβCD and raloxifene in water. Phase solubility studies were performed according to the method reported by Higuchi and Connors . As given in Table 1, raloxifene was taken into vials in an excess amount, and 20 ...Abstract. This current work has been conducted mainly to increase solubility and drug release properties for high hydrophobic Dentatin (DEN) by incorporation it into …[Article] - Phase Solubility Techniques I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv.Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.

In a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the guest...Higuchi and Connors, "Phase-Solubility Techniques,", 1964, Box: 11, Folder: 35. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer …Phase solubility evaluates the solubility of insoluble guest molecule in the presence of cyclodextrin. It can be obtained by studying the relationship between the guest molecule (1,8-cineole) and the host molecule (HP-β-CD) in the solution, and the stability of IC can be evaluated by stability constant (K s ) ( Higuchi & Connors, 1965 ).Solubility diagrams were obtained according to Higuchi and Connors (1965). Excess amounts of sulfamethizole were added to water containing various concentrations of cyclodextrins and the suspensions were shaken at 37°C. ... Phase solubility techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus Google Scholar. Job, …

K state football radio station.

(1970). Phase Solubility Analysis. C R C Critical Reviews in Analytical Chemistry: Vol. 1, No. 2, pp. 193-215.Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH.The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation.The solubility as a function of HPβCD concentration of the charged and …Fig. 1 shows the phase solubility diagrams of sulfamethizole with the cyclodextrins used, BCD and HPBCD, at 37°C. The solubility of the drug increased linearly as a function of the CD concentration, a feature of the A L-type complex, showing that water-soluble complexes exit in solution.T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117–212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135–149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...

The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...The phase solubility curve can be classified as an A L-type diagram, according to the Higuchi and Connors classification (Higuchi and Connors, 1965). The slope of the solubility diagram (0.70) was lower than 1, indicating the formation of 1:1 (mol/mol) ACV-SBE-β-CD inclusion complex.method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .In the present study, the solubility of aniracetam alone was 4.53 mg/mL. This is a significant increase from 0.109 mg/mL, which is reported in the literature . The marked increase in apparent solubility may be explained by the limited samples used within the phase solubility analysis at lower HP-β-CD concentrations.Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors ().The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. …Indeed, the absorption coefficient of THC in the complex depends on ligand concentration within the solution. Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965).There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience. 3.8. Solubility Studies. The phase-solubility profiles of the three polymorphic forms of benzocaine were determined according to the method of Higuchi and Connors , and were performed by using a Thermo Scientific™ MaxQ™ 4450 Benchtop Orbital Shaker (Thermo Scientific, Waltham, MA, USA). To 25.0 mL flasks, containing 10.0 mL methanol …The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl) …Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro …The effects of βCD and MβCD on the solubility of SMT were studied as follows: an excess of SMT was added to aqueous buffered solutions of pH 2.0, pH 8.0, or water containing different amounts of βCD (0–13.2 mM) or MβCD (0–105 mM for water and 0–84 mM for pH 2.0 and 8.0). The resulting suspensions were sonicated in an ultrasonic …Dec 15, 2014 · Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added.

Higuchi T, Connors K. Phase-solubility techniques. Adv Anal . Chem Instr 1965;4:117-22. ... Microwave Irradiation Technique, a Green Chemistry Approach for Dissolution Enhancement of Lopinavir.

AAPS PharmaSciTech 2005;6:464–72. 18. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117–212. 19. Higuchi T, Kristiansen H. Binding specificity between small organic solutes in aqueous Solution, Classification of some solutes into two groups according to binding tendencies. J Pharm Sei 1970;59:1601–8. 20.Feb 28, 2023 · According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ... PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE J Pharm Sci. 1964 Nov;53:1325-8. doi: 10.1002/jps.2600531108. Authors L W DITTERT, T HIGUCHI, D R REESE. PMID: 14253586 DOI: 10.1002/jps.2600531108 No abstract available. MeSH terms Chemistry, Pharmaceutical* ...23 Ağu 2019 ... Figure 3: Higuchi-Connors diagram showing total substrate solubility versus CD concentration. A-type diagrams relate to the water-soluble ...Abstract. Levemopamil was solubilized by varying the concentration of hydroxypropyl- β -cyclodextrin (HP β CD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HP β CD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HP β CD concentration of the charged ...Phase solubility studies. The impact of the presence of BCD on the aqueous solubility of propolis extract was measured at different temperatures. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Saturated solution of BCD (15 mM) was prepared, heated at 50 °C and shaken until complete ...Phase solubility study. Phase solubility studies were carried out according to the method reported by Higuchi and Connors . Excess amounts of MMF were added to 0.1 N HCl solutions (pH-1.2) containing para sulphonatocalix[4]resorcinarene in different molar concentrations and these flasks were then sonicated for 1 h and shaken at a rate …

Indiana kansas basketball tickets.

Apa formator.

Phase-solubility techniques 来自 scienceopen.com 喜欢 0. 阅读量： 717. 作者： TK Higuchi ， A Connors.phase solubility technique in studying the formation of complex salts of triamterene j pharm sci. 1964 nov;53:1325-8. doi: 10.1002/jps.2600531108.ResearchGate | Find and share researchThe phase solubility study was performed in water as per the reported method by Higuchi and Connors . An excess amount of resveratrol was added to a solution containing an increasing concentration of nanosponges. ... Higuchi, T., Connors, K.A.: Phase solubility techniques. In: Advances Analytical Chemistry and Instrumentation, …Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different …The linear phase solubility diagram follows the A L-type model according to Higuchi and Connors (1965), suggesting the inclusion complex formed between BBH (guest) and β-CD (host) is in molar ratio of 1:1. It is well-known that the most common type of CDs complexes is the 1:1 drug/cyclodextrin complex where one drug molecule forms a …At 298.2–318.2 K and 101.1 kPa, the solubility of FBX in several mono solvents was measured using an experimental approach proposed by “Higuchi and Connors” . The extra FBX was mixed with the known amount of each mono solvent. The obtained suspensions were vortexed for 10 min.2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...Aug 8, 2022 · Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ... Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on …Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added. ….

Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117–212. [Google Scholar] 26. Doile KM ...All the phase solubility diagrams displayed a typical AL type diagram (i.e. linear increases in luteolin solubility with increasing CD concentrations) within the concentration range studied, indicating a 1:1 stoichiometry of the complexes between luteolin and the five different CDs studied (Higuchi & Connors, 1965). This means that each ...Indeed, the absorption coefficient of THC in the complex depends on ligand concentration within the solution. Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965).Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α-CD and taken in …Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this article at. ScienceOpen Bookmark. There is …In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation. Higuchi connors phase solubility techniques, Phase-solubility profile indicated that the solubility of DMA was significantly increased in the presence of βCD (33-fold) and was classified as A L -type, indicating the …, All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ..., Indeed, the absorption coefficient of THC in the complex depends on ligand concentration within the solution. Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965)., Phase solubility studies. The impact of the presence of BCD on the aqueous solubility of propolis extract was measured at different temperatures. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Saturated solution of BCD (15 mM) was prepared, heated at 50 °C and shaken until complete ..., According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ..., Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH.The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation.The solubility as a function of HPβCD concentration of the charged and …, The linear phase solubility diagram follows the A L-type model according to Higuchi and Connors (1965), suggesting the inclusion complex formed between BBH (guest) and β-CD (host) is in molar ratio of 1:1. It is well-known that the most common type of CDs complexes is the 1:1 drug/cyclodextrin complex where one drug molecule forms a complex ..., The complexation of diosmin with βCD and HPβCD both indicated an AL type of phase-solubility diagrams, and the apparent stability constants (Kc) was found to be 222.13 and 200.08 M(-1 ..., The effect of β-CD on the solubility of atorvastatin was investigated according to the phase solubility technique reported by Higuchi and Connors . Excess amounts of atorvastatin were added to 20 mL of either double-distilled water or aqueous solutions containing increasing concentrations of CDs, ranging from 5 to 15% w/w, in a …, 2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …, Phase solubility studies. The impact of the presence of BCD on the aqueous solubility of propolis extract was measured at different temperatures. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Saturated solution of BCD (15 mM) was prepared, heated at 50 °C and shaken until complete ..., According to the Higuchi and Connors classification [6], the phase solubility diagram for the repaglinide – HP- β-CD inclusion complex is A type, which indicates the formation of a soluble complex., complexation is the phase so lubili ty method carr ied o ut according to Higuchi and Connors method [14][15] , which examines the e ffec t of nanospo nges on the solubility o f the drug. An, ResearchGate | Find and share research, Phase-solubility measurements. Phase-solubility measurements were carried out according to the method of Higuchi and Connors.14 Excess amount of 5-NI. ( ..., The linear phase solubility diagram follows the A L-type model according to Higuchi and Connors (1965), suggesting the inclusion complex formed between BBH (guest) and β-CD (host) is in molar ratio of 1:1. It is well-known that the most common type of CDs complexes is the 1:1 drug/cyclodextrin complex where one drug molecule forms a complex ..., Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ..., Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, …, Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0-4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ..., 2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …, Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; Chemistry, complexation is the phase so lubili ty method carr ied o ut according to Higuchi and Connors method [14][15] , which examines the e ffec t of nanospo nges on the solubility o f the drug. An, Phase-solubility measurementsPhase-solubility measurements were carried out according to the method of Higuchi and Connors. 14 Excess amount of 5-NI (5 mg) was added to 5 mL of deionized water containing increasing amounts of βCD and DM-βCD (ranging from 0 to 0.010 M)., 1 Ara 2009 ... Solubility Studies—Phase Solubility Experiments. Equilibration Time ... Higuchi T, Connors K. Phase-solubility techniques. Adv Αnal. Chem ..., In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation., There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience., The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, …, [16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-150, 1965. [17] T. Higuchi, H. Kristiansen, “Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies”, Journal …, All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene …, Article Original Paper Published: 08 August 2022 Mangiferin/ β -cyclodextrin complex: determination of the Inclusion constant in aqueous solution by Higuchi-Connors method and molecular absorption and photoluminescence UV spectroscopies at pH 3.4 Lucero Hernández-García, Alberto Rojas-Hernández & Annia Galano, Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ..., The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBCD. Both the pH and the type of buffer used to adjust the medium pH had a very significant effect on drug solubilities and the apparent binding ..., Phase solubility analysis. The phase solubility diagram for DEN and HPβCD obtained based on the methods of Higuchi and Connors 1965 (Fig. 3) can be categorised as AL-type. The solubility of DEN increases linearly with increase HPβCD concentration. The stability constant K was obtain from the linear portion in the phase solubility diagram ...